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Recently, a patient with a history of bipolar disorder and lupus successfully tapered off of Seroquel. She has been off her medication since July 2017, after being dependent on this medication for over 15 years.
In her journey to maintain mental health, we came to a better understanding of how high levels of histamine could undermine mental health.
Histamine is a neuromodulator of the adrenals and can increase levels of adrenaline. Stress and inflammation are associated with increased histamine, as well as withdrawal from histamine-blocking medications, e.g. Seroquel.
Her symptoms of extreme fatigue, anxiety, and cognitive confusion resolved when she introduced a temporary break from work, began a low histamine diet, and added a DAO histaminase enzyme supplement.
Here is a great article on histamine and its role in our health. If you ever want to successfully reduce a medication that blocks histamine receptors, you will need to know how to lower histamine levels.
All the best,
Alice W. Lee, MD